Picking up where the first film left off, the two remaining assassins, Azumi and Nagara, pursue their final target, Masayuki Sanada. However, Sanada knows they are coming. He has hired the Koga Ninja Clan, masters of stealth, infiltration and fighting, to kill Azumi before she can complete her mission. Hot on Azumi's heels is Kanbei, the failed retainer of Kiyomasa, the last warlord Azumi assassinated with her own sword. He seeks revenge, and will stop at nothing to get it. The whirlwind chase of the hunters and hunted rages-who will be left alive?